—To give an overview of (1) pathologic changes that occur during. To apply this medicine use a cotton-tipped applicator, or use gloves if applying with fingertips. Appearance of a patient before and after topical application of fluorouracil cream, 5%, to the entire face twice daily for 2 weeks. Aims To determine the level of vascular endothelial growth factor (VEGF) in the plasma of patients with diabetic macular edema (DME) and of patients with exudative age-related macular degeneration (ARMD) before and after intravitreal injection of bevacizumab, ranibizumab or pegaptanib.